MYC and colorectal carcinoma: To address whether the recruitment of DOT1L and the activating H3K79 di-/tri-methylation mark to TCF4/β-catenin target genes is mediated by MLLT10/AF10, we depleted MLLT10/AF10 from Ls174T CRC and performed ChIP probing recruitment of DOT1L and H3K79 di-/tri-methylation on AXIN2 and c-MYC (Figure 6).