GRM5 and Lewy body dementia: In support of this interaction hypothesis we showed a greater degree of mGluR5 and alpha-syn co-immunoprecipitation in the alpha-syn tg mice compared to non-tg mice and a greater accumulation of mGluR5 in the membrane fractions from DLB or PD cases and in alpha-syn tg mice compared to control cases or non-tg mice.