CREB activation (ratio of pCREB/tCREB) was increased in the nuclear fraction from the DLB and PD cases when compared to controls (Figure 6C, I), In the cytoplasmic fraction, both DLB and PD cases displayed increased ERK activation (ratio pERK/totalERK) compared to control cases (Figure 6B, F). Here, CREB1 is linked to Lewy body dementia.