INS and type 2 diabetes mellitus: CDKN2A/2B encodes for p16INK4a, a tumor suppressor influencing pancreatic β-cell proliferation [37], [38].It is possible for a causal variant situated in CDKN2A/2B to increase the susceptibility of T2DM through β-cell mass reduction and subsequent insulin release impairment in the sates with increased insulin demand.