Overexpression of AT1-R has also been demonstrated in vivo in different tumours, including: oestrogen receptor positive breast cancers (Rhodes et al, 2009), glioblastomas (Juillerat-Jeanneret et al, 2004), ovarian cancers (Suganuma et al, 2005), squamous cell carcinomas of the skin (Takeda and Kondo, 2001) and gastric cancers (Rocken et al, 2007). Here, AGTR1 is linked to breast carcinoma.