AKT1 and neoplasm: Indeed, ATII through AT1-R can activate tumour cell proliferation through at least two simultaneous mechanisms: PI3-kinase/Akt pathway (Zhao et al, 2010) and EGFR (epithelial growth factor receptor) trans-activation (Fujiyama et al, 2001; Greco et al, 2003; Uemura et al, 2003).