The changes in the Alb–cre Sav1 null livers seem to be attributable entirely to the oval cell compartment; adeno–Cre infection of isolated Sav1ff oval cells in vitro results in increased abundance and phosphorylation of Yap and Lats1 as well as more Mst1 polypeptide, paralleling the changes seen in the Alb–cre Sav1 null liver, whereas Sav1 deletion from isolated hepatocytes gives little change in the abundance or phosphorylation of these elements (Le et al, 2010). This evidence concerns the gene ALB and infection.