Mutations in Mst1/2, Lats1/2 and Sav1 in human cancers are very infrequent in the COSMIC catalogue, however there is evidence of promoter silencing by hypermethylation in some cancer types (e.g., Lats1/2 in breast cancers; Takahashi et al, 2005). This evidence concerns the gene LATS1 and breast cancer.