Whereas Yap phosphorylation is markedly reduced by the acute elimination of Mst1/2 with adenoviral–cre, they find that phosphorylation of Lats1/Lats2 in liver is not significantly changed, nor is it altered by restoration of Mst1 into Mst1/2 null HCC cells; in contrast Le et al (2010) find Lats1/2 phosphorylation to be diminished in the Alb–cre/Mst1/Mst2 double knockout liver. Here, MST1 is linked to hepatocellular carcinoma.