In addition, recent studies have shown that Annexin1 (ANXA1), which was listed as a gene downregulated by BRG1 knockdown, regulates TGF-β signalling and promotes metastasis formation (de Graauw et al, 2010); loss of ANXA1 was associated with tumour progression in human breast cancer (Shen et al, 2006). This evidence concerns the gene SMARCA4 and breast carcinoma.