However, increased expression of BRG1 was oppositely oncogenic and indispensable for transformation of human cervical, rhabdoid and colon cancer cells: BRG1 permitted cancer cell proliferation in cooperation with the histone acetyl transferase protein, CREB-binding protein, to suppress p53 activity (Naidu et al, 2009). This evidence concerns the gene SMARCA4 and malignant colon neoplasm.