Although BRG1 contributed to tumour suppression by interaction with Rb (Dunaief et al, 1994; Strober et al, 1996; Dahiya et al, 2000) and p53 (Bochar et al, 2000), other BRG1-related mechanisms may exist for the promotion of tumour growth in CRC. Here, TP53 is linked to colorectal carcinoma.