SMARCA4 and breast cancer: In addition, recent studies have shown that Annexin1 (ANXA1), which was listed as a gene downregulated by BRG1 knockdown, regulates TGF-β signalling and promotes metastasis formation (de Graauw et al, 2010); loss of ANXA1 was associated with tumour progression in human breast cancer (Shen et al, 2006).