PTEN and neoplasm: Furthermore, co-transfection of BRG1 siRNA and p-Akt1 restored cell growth accompanied by upregulation of p-Akt, p-GSK-3β and cyclin D1 levels (Figure 4C and D), whereas transduction of PTEN siRNA decreased tumour-suppressing effect of BRG1 silencing (Figure 4E and F).