Correspon-dingly, high fat cholesterol diet (HFHC)-fed mice deficient in low-density lipoprotein (LDL) receptor ligand ApoE (ApoE−/−) and rabbits on fat-enriched diet, feature high LDL and oxidized LDL (oxLDL) plasma levels [19-21] and exhibit ultrastructural retinal changes similar to those observed in human AMD [22], including BM thickening and BM lipid deposits [23-25]. Here, APOE is linked to age-related macular degeneration.