Consistent with the Drosophila data, the rapamycin analogue CCI-779 reduces both mutant huntingtin and ataxin-3 levels, thereby attenuating toxicity in mouse models of HD and spinocerebellar ataxia type 3, respectively (Menzies et al., 2010; Ravikumar et al., 2004). The gene discussed is HTT; the disease is Huntington disease.