The multi-preventive effects of metformin on type II diabetes and evolving cardiovascular complications include a decrease in total cholesterol and low density cholesterol (LDL), free fatty acids, tissue plasminogen activator antigen and insulin levels when patients present with symptoms of hypertension, dyslipidemia, visceral obesity or hyperglycemia [31] in contrast to such reviews we find unusual high percentage of hypertension even with or without glycemic control and decrease in LDL and total cholesterol. This evidence concerns the gene INS and Hypertension.