Our study identified a large number of genes associated with the extracellular matrix (SPARC, SERPINH1/HSP47, COL1A1, COL1A2, COL4A1, MMP3, TIMP1, PRSS2, CDH3, SPP1, IL8, CTSB, LUM, CEACAM, CTHRC1, SULF1, ASPN, SPON2 and CLDN18) and chemokine activity, to be differentially expressed in gastric cancers. Here, CTSB is linked to gastric cancer.