Furthermore, the simultaneous suppression of Dll4/Notch and Ephrin-B2/EphB4 signaling in sEphB4-Alb treated RT2 Dll4+/- mice drastically reduced the vessel diameters and their mural cell coverage, even though the total PECAM-positive area apparently similar to PBS-treated Dll4+/+ insulinomas (Figure 3C and 3D). This evidence concerns the gene DLL4 and pancreatic insulinoma.