Similarly, sEphB4-Alb, which blocks Ephrin-B2 mediated forward signaling in venous endothelial cells through its cognate receptors, in particular EphB4, and reverse signaling in the arterial endothelial cells expressing Ephrin-B2, reduces the rate of tumor growth without affecting the number of oncogenic tumor nodules in the pancreas. Here, EPHB4 is linked to neoplasm.