Therefore, after investigating the breast tumor at the genetic and expression level, we for the first time provide an integrated information on methylation patterns of the DDR and death receptor apoptotic pathway genes (TRAIL, DR4, DR5, DCR1, DCR2, CASP8, FLIP, BCL2, CYCS, ATM, TP53, BRCA1, BRCA2, H2AX, RNF8, TIP60 and CHEK2) in sporadic breast tumors, using high throughput automated MALDI TOF [17-19,22]. The gene discussed is RNF8; the disease is breast neoplasm.