On the basis of BRCA2 -26 GA heterozygotes observed earlier by us with a protector genotype, showing decreased LOH; and the risk providing GG/AA homozygotes showing increased LOH [6], we suggest that the presence of hypermethylated DR5, CASP8, BRCA2 and hypomethylated FLIP with BRCA2 -26 GG or AA genotype, might cause increased LOH, decreased DNA repair and apoptosis, providing a risk for sporadic breast tumor development and progression. This evidence concerns the gene CASP8 and breast neoplasm.