Tumor tissue showed hypomethylation for DR4, FLIP, and RNF8 and hypermethylation for DR5, DCR1, DCR2, CASP8, CYCS, BRCA1, BRCA2, whereas H2AX, TRAIL, BCL2, ATM, CHEK2, TP53 and TIP60 did not show any significant difference between the breast tumor and the corresponding normal tissues. Here, H2AX is linked to breast neoplasm.