Categorization of breast tumor samples on the basis of BRCA2 -26 G/A 5'UTR polymorphism, followed by methylation status of the candidate genes resulted in the identification of GG and AA genotypes to be associated with hypermethylated BRCA2 (63%;P = 0.008) , DR5 (69%;P = 0.001), DCR1 (67%; P = 0.0001), DCR2 (76%;P = 0.0000002), CASP8 (59%;P = 0.006) and hypomethylated FLIP (59%;P = 0.009). This evidence concerns the gene TNFRSF10C and breast neoplasm.