Multivariate analysis controlling for age, tumour size, nodal status, grade, ER, PR and Her2 status revealed that an increased survivin CNR was a predictor of a prolonged BCSS (HR 0.47, 95% CI 0.27-0.82, p = 0.008), along with tumour grade and lymph node status (Table 2). Here, ESR1 is linked to neoplasm.