Multivariate Cox regression analysis controlling nodal status, grade, ER status, PR status, Her2 status, tumour size and age revealed that SNAS was an independent predictor of OS (HR 1.68, 95% CI 1.22-2.32, p = 0.002) and BCSS (HR 1.84, 95% CI 1.10-3.08, p = 0.02), along with lymph node status, grade and age (Table 2). Here, ESR1 is linked to neoplasm.