PFKFB2 and acute lymphoblastic leukemia: PFKFB2 was identified by microarray analysis of lymphoblasts isolated from GC-treated children suffering from ALL [5] as one of the most promising candidate genes, since it was regulated in the majority of patients and its deregulation should entail disturbances in glucose metabolism which, in turn, have been implicated in cell death induction in general [12,13].