PFKFB2 and acute lymphoblastic leukemia: In hyperdiploid precursor B-ALL children, isoform PFKFB2-15A was upregulated in 5/7 cases, with one child presenting a tendency for downregulation (M-value = -0.6), while PFKFB2-15B induction was present only in 1 of the 7 children after 6 hours.