GC-resistant cell lines and non-leukemic individuals (whose peripheral blood lymphocytes are considered resistant to GC-induced apoptosis)[34,35], clearly showed less GC-induction of PFKFB2. Thus, even though the correlation of GC-induction of PFKFB2 and cell death was not complete, the extended expression/regulation analyses further supported a possible role of PFKFB2 in GC-induced apoptosis, particularly in T-ALL cells. Here, PFKFB2 is linked to acute lymphoblastic leukemia.