PFKFB2 and acute lymphoblastic leukemia: Interestingly, the second GC-sensitive ALL cell line tested in this study, 697/EU-3, and mouse thymocytes failed to regulate PFKFB2. In conclusion, PFKFB2 was induced in many primary ALL cells (particularly T-ALLs), but not in non-malignant lymphoid lineage cells, raising the possibility that this gene might play a functional role in GC-induced apoptosis in malignant lymphoid cells such as ALL.