As LEF-1 has been shown to be a target of TCF4/β-catenin [14], we speculated that tumour progression may be accompanied by a shift of β-catenin binding partners from TCF4 to LEF1 and we therefore expected to find TCF4 positivity mainly in central tumour areas and LEF-1 mainly in the front of invasion. Here, TCF4 is linked to neoplasm.