To compare caspase-3 activity induced by SV119, SW43, and SRM, Panc02 mouse adenocarcinoma cells were treated with sigma-2 ligands (25 μM) for 18 hours and assayed for cleavage of the caspase-3 fluorogenic substrate Ac-DEVD-AMC. This evidence concerns the gene AP2S1 and adenocarcinoma.