Our data do not rule out the speculation that the increased permissiveness to HIV-1 infection resulting from BTBD2 silencing might in some way relate to the co-localization of BTBD1 and BTBD2 with TRIM5 proteins in cytoplasmic bodies or the involvement of BTBD1 and BTBD2 with other factors that may influence permissiveness to HIV-1 infection [25]. Here, TRIM5 is linked to HIV-1 infection.