LTF and cancer: Additional corroboration that inhibition of VEGF-induced angiogenesis in the tumor-free mesentery may reflect significant events leading to inhibition of tumor growth comes from the fact that systemic treatment with bovine iron-unsaturated lactoferrin suppresses VEGF-induced angiogenesis in the rat mesentery model (39), as well as cancer cell-induced angiogenesis in a mouse dorsal air sac assay (40).