to improve the quality of care of patients and their families with any condition resulting in hereditary gastrointestinal tumours.” The InSiGHT consortium maintains a LOVD-based database for genetic variations for the EPCAM, MLH1, MLH3, MSH2, MSH6, MUTYH, PMS1, and PMS2 genes leading to gastrointestinal tumors and encourages the establishment of national repositories for patients suffering from gastrointestinal tumors, particularly in developing countries. This evidence concerns the gene PMS2 and digestive system neoplasm.