During an immune response, the CD8+ T cells take a leading role in infection immunity and exert several effector functions[12-16] and also become the regulatory target in tumor immunity and autoimmunity.[8, 15] It is possible that GITR, as one of the newly identified TNFR members, may have some critical immunoregulatory role on CD8+ T cells, which is highly important for further evaluation. This evidence concerns the gene TNFRSF18 and infection.