For example, HLA allele polymorphisms HLA- B*5301, HLA- DRB1*1302, and HLA- DRB1*0101 have been associated with genetic resistance [20-22] or HLA-DRB1*04 with susceptibility [23] to malaria, but the distribution is different in different populations where malaria is endemic [19,20,24]. This evidence concerns the gene HLA-DRB1 and malaria.