For example, in scleroderma, reduced expression of Fli1 in skin fibroblasts and endothelial cells is implicated in the fibrotic and vascular components of the phenotype [49], while in lupus elevated expression of Fli1 in mononuclear cells is thought to contribute to the disease phenotype [3]. The gene discussed is FLI1; the disease is systemic lupus erythematosus.