We observed a slightly stronger transmission disequilibrium of the obesity haplotype [A; G] of Haplo 3 (transmission-ratio = 1.56; Table 3) if it included the wild-type, ‘obesogenic’ alleles of the two non-synonymous MC4R polymorphisms as compared to the situation of an un-stratified assessment of omitting the two polymorphisms (transmission-ratio = 1.55; Table 4). The gene discussed is MC4R; the disease is obesity due to melanocortin 4 receptor deficiency.