Global transmission disequilibrium tests (HAP-TDT) of all three best two-marker haplotype combinations (according to p-values) in the genomic region covering the melanocortin 4 receptor gene (MC4R) in 424 obesity trios of the detection sample, the confirmation sample of 363 obesity trios and in the joint sample of 787 obesity trios. This evidence concerns the gene MC4R and obesity due to melanocortin 4 receptor deficiency.