MC4R and obesity due to melanocortin 4 receptor deficiency: Accordingly, the obesity alleles of the common obesity-associated SNPs outside of the MC4R coding region (rs12970134 and rs1943229) were less frequently transmitted to obese offspring in the presence of the weight-lowering variants of the two MC4R polymorphisms (Val103Ile and Ile251Leu; Table 3; left panel) as indicated by transmission-ratios below 1.