Similarly, joint modelling of the effects of the two distant SNPs and the non-synonymous MC4R polymorphisms collapsed into one covariate [20] resulted in hardly any change of the obesity effects of the two distant SNPs (Table 5; left panel; rs12970134, A allele: RR 1.45 to 1.43; rs1943229, G allele: RR 1.23 to 1.24), while the effect for the collapsed wild-type alleles of the two non-synonymous MC4R polymorphisms was slightly reduced (RR 1.66 to 1.54 [20]). This evidence concerns the gene MC4R and obesity due to melanocortin 4 receptor deficiency.