On the other hand, NQO1 (NAD(P)H dehydrogenase, quinone 1; EntrezGene ID: 1728), whose inactivating mutation has been associated with colon cancer in animal models and in human population studies [38], is markedly down-regulated in cancer samples (t-test nominal p-value  =  2.4×10−6, 66.5% average reduction compared to control). The gene discussed is NQO1; the disease is malignant colon neoplasm.