MGST1 and malignant colon neoplasm: Specifically, MGST1 (Microsomal glutathione S-transferase 1; EntrezGene ID: 4257) is markedly down-regulated (t-test nominal p-value  =  6.9×10−5, 65.0% average reduction compared to control) and certain MGST1 polymorphisms have been associated with increased colon cancer risk [39].