Shipley et al. [32] found that HSV-1 infection of neuroblastoma cells led to the appearance of a 55-kDa C-terminal fragment of APP, and Wozniack et al. [33] found that BACE1 (β-secretase) and nicastrin (an essential component of γ-secretase complex) immunolabeling is increased in the brains of HSV-1-infected mice. Here, APP is linked to neuroblastoma.