No correlation could be observed between NT-3 serum levels and NGF and BDNF concentrations either in the SSc group (NGF r = 0.11, NS; BDNF r = 0.05, NS) or in the controls (NGF r = 0.06, NS; BDNF r = 0.09, NS). This evidence concerns the gene NTF3 and systemic sclerosis.