Since false negative associations due to the limited sample size should be taken into account especially for vaspin, leptin, IL-6, adiponectin and RBP4 further studies with extended sample size are required to elucidate the relative role of the different adipokines in relation to deterioration of glucose metabolism from IFG to IGT and ultimately T2D. The gene discussed is RBP4; the disease is type 2 diabetes mellitus.