We also analyzed serum samples for antigen specific antibody isotypes in the sera samples from children in the cohort and found that IgG2 antibody reactivity to both specific malaria antigens (MSP-1 and AMA-1) in the malaria-infected groups (M and S+M) was markedly increased compared to the reactivity of malaria-free control groups (N and S) at T0 ( Figures 7a and 7b). The gene discussed is ATAD1; the disease is malaria.