Multivariate adjustment has shown that the sulfonylurea cohort had greater cancer-related mortality compared with the metformin cohort (1.3 (95% CI 1.1-1.6); p = 0.012), whereas insulin use was associated with an adjusted cancer-related mortality of 1.9 (1.5 - 2.4; p < 0.0001). This evidence concerns the gene INS and cancer.