Prasad et al. found that pathogen burden and CRP levels interacted significantly such that carriers of 4-5 pathogens and elevated CRP levels (> 0.5 mg/dL) had higher odds of coronary artery disease compared to those with fewer pathogens [4], supporting the notion that pathogen burden along with inflammation has a stronger impact than any one pathogen alone or inflammation alone. This evidence concerns the gene CRP and coronary artery disorder.