Two-weeks of the GPER agonist G-1 infusion in either the HS or the NS group did not significantly alter systolic blood pressure [G-1: F(1,18) = 3.88, P = 0.064), despite the fact that the HS diet markedly exacerbated systolic hypertension in comparison to NS (Figure 2). This evidence concerns the gene GPER1 and hypertensive disorder.