Circulating levels of Ang-2 have been shown to correlate with poor patient survival in other cancers including melanoma and lung cancer (Park et al, 2007; Helfrich et al, 2009), and patients with metastatic colorectal cancer have higher levels of serum Ang-2 than healthy controls (Goede et al, 2010). The gene discussed is ANGPT2; the disease is melanoma.