Mean silencing of TSPAN8 transcripts averaged 89±4.6 and 72±5.8% at 2 and 5 days post-transfection, respectively (n=3), without significant impact on the expression of other two major tetraspanins expressed by both melanoma clones: CD9 and CD151 (Figure 4C and D), thus demonstrating the specificity of the silencing effect. The gene discussed is CD151; the disease is melanoma.