TSPAN8 and melanoma: In contrast, melanoma cells stained strongly positive for TSPAN8 in primary melanomas and in lymph nodes (Figure 3B): immunoreactivity was observed in 8 of the 13 RGP lesions, in 10 of the 35 VGP lesions and in 2 of the 6 lymph node metastases (Supplementary Table S5).