TSPAN8 and melanoma: The correlation between TSPAN8 expression and aggressiveness was not restricted to our melanoma model, as SKMel28 and WM793 melanoma cell lines, chosen because they are able to invade dermis in human skin reconstructs (Hsu et al, 2008; Lasithiotakis et al, 2008), also expressed TSPAN8 on their cell surface (Figure 3A).