TSPAN8 and neoplasm: Some of them encode for proteins involved in cell adhesion and actin-based motility, including ICAM2, α2-actin (ACTA2), autocrine motility factor/glucose phosphate isomerase, extracellular matrix serine protease (RELN), pigment epithelium-derived factor (SERPINF1), a tetraspanin family member (TSPAN8) and CAPG (capping protein-actin filament-gelsolin-like) (Supplementary Table S4), highlighting the well-known importance of tumour cell interaction with the extracellular matrix during invasion.