The authors characterised two HER-2-positive subtypes based on the in silico analysis of 42 tumour samples with increased expression of HER-2-related genes, with the low recurrence subtype being associated with a relative overexpression of lymphocyte-associated genes and prominent lymphocytic infiltration on histological analysis of 13 independent tumours, of which only 10 were available for evaluation. This evidence concerns the gene ERBB2 and neoplasm.