Observations that SOSTDC1 is expressed in normal renal tissue and that its expression is decreased in renal cancer ([16]; Figure 1) coupled with this secreted protein's role in modulating the cancer-relevant BMP and Wnt signaling pathways, led us to hypothesize that LOH within the SOSTDC1 locus may contribute to renal tumor development. This evidence concerns the gene SOSTDC1 and kidney neoplasm.