In this study, we showed by meta-analysis of 7 studies summarizing 2364 hip OA cases and 6773 controls, 1983 knee OA cases and 4706 controls and 1431 hand OA cases and 3883 controls, that common genetic variation in the ESR2 gene is not likely to be associated with an increased risk of osteoarthritis. Here, ESR2 is linked to osteoarthritis.