The cytotoxic action of synthetic phospholipid analogs relies on their ability to affect specific signaling processes in the tumor cells such as the proapoptotic stress-activated protein kinase (SAPK)/c-jun-NH2-terminal kinase (JNK) pathway, the prosurvival PI3K/Akt pathway, and the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway [9]. The gene discussed is AKT1; the disease is neoplasm.