LAT and eye infection: Critical examples include findings that show that during latency the LAT promoter and the LAT 5′exon (a gene region containing an enhancer element and critical for reactivation [20], [24]) regions are highly enriched in the transcriptionally permissive (euchromatic) histone marker acetyl H3 K9, K14 when compared to the immediate early (IE) promoters of ICP0, ICP4, and ICP27 in the footpad and ocular infection mouse models [19]–[22].