Normal mammary tissue CD44+/CD24−/low stem cells showed a prominent innate immune response to infection with oncolytic virus: 1.6 and 4.8 fold induction of IFNα at 4 h and 24 h time points and 2.5 fold induction of IFNβ at 4 h respectively were detected (Fig. 7A). This evidence concerns the gene IFNB1 and infection.