Colocalization analysis of TLR9 and MyD88 to ER or endosomes in JIMT-1 CD44+/CD24−/low CICs showed that neither TLR9 nor MyD88 fully reaches endosomes in 4 h and 6 h respectively (Fig. 6B), whereas in the CD44−/CD24− non-CIC population localization became endosomal upon virus infection (Fig. 6B). This evidence concerns the gene MYD88 and viral infectious disease.