However, TUDCA did not reduce the expression of Pparg, which is a critical transcription factor in development of hepatic steatosis in ob/ob mice [42], and its direct target genes (e.g., Cidec, Cd36, and Ucp2), suggesting that the TUDCA effect in improving hepatic steatosis is Pparg-independent (Figure S5). Here, UCP2 is linked to Hepatic steatosis.