TF and Parkinson disease: Iron uptake, which can occur via a Ca2+ activated non-transferrin bound iron (NTBI) mechanism in PC12 cells [37]–[40], is associated with several neurodegenerative diseases including PD and Alzheimer's [41] (in PD, oxidative stress hypothesis leads to increased iron concentration in the substantia nigra that induces progressive dopaminergic neuronal degeneration secondary to a high production of hydroxyl radicals by Fenton reaction [42]).