In order assess the baseline expression and the RV mediated induction of RIG-I and MDA5 protein in bronchial epithelium in vivo, bronchial biopsies were taken from 15 normal adult volunteers before experimental RV16 infection (baseline) or at day 4 post infection and stained for RIG-I and MDA5 by immunohistochemistry. This evidence concerns the gene IFIH1 and infection.