CD4 and tropical spastic paraparesis: With a unique cohort of 30 HTLV-1-infected individuals from the Caribbean basin and a custom ImmuneArray [50], we identified ∼1039 significant immune-related genes that were differentially regulated in CD4+ T cells from 11 AC, 7 ATL, 12 HAM/TSP patients, compared with CD4+ T cells from 8 NI donors from the same geographical region.