To analyze gene expression profiles of CD4+ T cells isolated from HTLV-1 infected patients, we gathered a unique cohort of 30 HTLV-1 infected individuals from the Caribbean basin, including 11 AC, 7 ATL, 12 HAM/TSP and 8 healthy, non-infected donors (NI) (Table S1). The gene discussed is CD4; the disease is tropical spastic paraparesis.