This approach has been applied to image the effects of targeted treatments of protein kinase inhibitors in cancer patients including monitoring the effects of Imatinib (Gleevec; STI571; Novartis) and Sunitinib (Sutent; SU11248; Pfizer) in patients with gastro-intestinal stromal tumors (GIST) [17,18]. The gene discussed is WEE1; the disease is cancer.