APC and desmoid tumor: The second issue is that it has previously been reported that there is a close association between the presence of a germline APC mutation between codons 1403 and 1578 in FAP patients and the occurrence of desmoid tumors [1,3], however, both of the FAP patients with a desmoid tumor in our series had a germline APC mutation outside the region, i.e., in codon 664 and codon 1249.