Because RUNX1 and EVI1 mutations are frequently reported in high-grade MDS at transformation to AML [37], and EVI1 overexpression is a poor prognostic and risk stratification marker in AML [41,42], we agree with Gondek and colleagues [5,6] that aCGH will improve patient management and prognostication in MDS. Here, RUNX1 is linked to acute myeloid leukemia.