NEFH and amyotrophic lateral sclerosis: The detrimental effect of neurofilaments aggregation on axonal transport is widely acknowledged [13], whilst the identification of motif deletions of the heavy neurofilament subunit gene [(Nfh); [15]] and of an increase in the levels of Nfh in the cerebrospinal fluid from ALS patients support the hypothesis that these cytoskeletal proteins are central in the pathogenesis of ALS [15,16].