CORO1A and lymphopenia: Mice with a homozygous missense mutation in the Coronin-1A (CORO1A) gene show severe T cell lymphopenia; this has suggested the recent discovery of the absence of Coronin-1A in a 13-month-old girl with AR T-B+NK+ SCID, by deletion of the entire CORO1A gene on one allele (600 kbs deletion in 16p11.2) and a dinucleotide deletion resulting in frameshift and premature termination on the other allele [102,103].