Although GCN2 expression has not been documented so far to be increased in any malignancy, PKR levels and/or activity have been reported to be elevated in breast cancer [35], melanoma and colon cancer cell lines [36] and hematological malignancies [37], raising the possibility that these cancers might be good candidates for treatment with these agents. The gene discussed is EIF2AK4; the disease is malignant colon neoplasm.