APOE and atherosclerosis: Gonen A et al. [24] studied the anti-atherosclerosis mechanism of pure allicin in ApoE-/-/LDLR-/- double-gene mutant mice, and results indicated that allicin could exert anti-atherosclerosis effects through lipoprotein modification or by inhibiting phagocytic uptake and degradation of LDL, except for antioxidant.